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RevMab
anti-p120-catenin (human), Rabbit Monoclonal (RM353)
459
CHF
CHF 459.00
In stock
REV-31-1239-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human kidney tissue section using anti-p120 catenin rabbit monoclonal antibody (Clone RM353) at a 1:5000 dilution.
| Product Details | |
|---|---|
| Synonyms | Catenin delta-1; Cadherin-associated Src Substrate |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM353 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the C-terminus of human p120 catenin (Catenin delta-1). |
| Application |
Immunohistochemistry (IHC): 1:1000-1:5000 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts human p120 catenin (Catenin delta-1). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | O60716 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Catenins are proteins associated with complexes that contain cadherin cell adhesion molecules. p120-Catenin (delta-1-catenin) is a member of the p120 Catenin subfamily and is a structural protein involved in neuronal development. It interacts with Actin, Cortactin and Src Kinases to promote neurite elongation or branching, depending upon its phosphorylation state. Like beta-catenin and gamma-catenin, delta-catenins appear to interact with presenilins. These catenin-presenilin interactions can impact cadherin function and regulation of cell-to-cell adhesion. While beta-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-catenin has been implicated as a regulator of the NF-kB transcription factor. p120-Catenin is an efficient tyrosine kinase substrate implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.