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RevMab
anti-CD5 (human), Rabbit Monoclonal (RM354)
Product Details | |
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Synonyms | T-cell Surface Glycoprotein CD5; Lymphocyte Antigen T1/Leu-1 |
Product Type | Recombinant Antibody |
Properties | |
Clone | RM354 |
Isotype | Rabbit IgG |
Source/Host | Rabbit |
Immunogen/Antigen | A peptide corresponding to the N-terminus (extracellular domain) of human T-cell surface glycoprotein CD5. |
Application |
Immunohistochemistry (IHC): 1:200-1:500 dilution |
Crossreactivity | Human |
Specificity |
This antibody reacts to human CD5 . |
Purity | Protein A purified. |
Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
Concentration | N/A |
Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
Isotype Negative Control | |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Accession Number | P06127 |
Declaration | Manufactured by RevMab Biosciences. |
Shipping and Handling | |
Shipping | BLUE ICE |
Long Term Storage | -20°C |
Handling Advice | Avoid freeze/thaw cycles. |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet | Download PDF |
CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome. CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3.