RevMab

anti-CD5 (human), Rabbit Monoclonal (RM354)

CHF 459.00
In stock
REV-31-1240-00-R100100 µlCHF 459.00
More Information
Product Details
Synonyms T-cell Surface Glycoprotein CD5; Lymphocyte Antigen T1/Leu-1
Product Type Recombinant Antibody
Properties
Clone RM354
Isotype Rabbit IgG
Source/Host Rabbit
Immunogen/Antigen A peptide corresponding to the N-terminus (extracellular domain) of human T-cell surface glycoprotein CD5.
Application

Immunohistochemistry (IHC): 1:200-1:500 dilution
Western Blot (WB): 1:10000-1:25000 dilution

Crossreactivity Human
Specificity

This antibody reacts to human CD5 .

Purity Protein A purified.
Purity Detail Protein A affinity purified from an animal origin-free culture supernatant.
Concentration N/A
Formulation Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Isotype Negative Control

Rabbit IgG

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Accession Number P06127
Declaration Manufactured by RevMab Biosciences.
Shipping and Handling
Shipping BLUE ICE
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome. CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3.

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