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RevMab
anti-Napsin-A (human), Rabbit Monoclonal (RM366)
459
CHF
CHF 459.00
In stock
REV-31-1252-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human lung adenocarcinoma tissue section using anti-Napsin-A rabbit monoclonal antibody (Clone RM366) at a 1:2000 dilution.
| Product Details | |
|---|---|
| Synonyms | Aspartyl Protease 4; ASP4; Napsin-1; TA01/TA02 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM366 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the N-terminus of human Napsin-A. |
| Application |
Immunohistochemistry (IHC): 1:500-1:1000 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts human Napsin-A. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | O96009 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Napsin-A is an aspartic proteinase that is abundantly expressed in normal lung and kidney tissue and is also frequently expressed in lung adenocarcinomas. Napsin-A has a role in processing pulmonary surfactant B protein produced by alveolar type II pneumocytes, therefore, it has been reported to be a good diagnostic marker for the confirmation of primary lung adenocarcinoma together with thyroid transcription factor 1 (TTF-1). Expression of napsin A is also observed in the fetal kidney and proximal tubules of the adult kidney, where it is most likely involved in protein catabolism. In neoplasms other than lung cancer, napsin A expression is most frequently observed in papillary renal carcinoma (79%), followed by other subtypes of renal cell carcinoma and thyroid carcinoma.