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RevMab
anti-Syntaxin-1A (human), Rabbit Monoclonal (RM367)
459
CHF
CHF 459.00
In stock
REV-31-1253-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue section using anti-Syntaxin-1A rabbit monoclonal antibody (Clone RM367) at a 1:1000 dilution.
| Product Details | |
|---|---|
| Synonyms | Neuron-specific Antigen HPC-1 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM367 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to residues near N-terminus of human Syntaxin-1A. |
| Application |
Immunohistochemistry (IHC): 1:500-1:1000 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human, mouse, and rat Syntaxin-1A. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q16623 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxin-1A (Neuron-specific antigen HPC-1) belongs to the Q-SNARE protein family that participates in exocytosis. Syntaxin-1A is a t-SNARE abundantly expressed in most neurons and localized on the neuronal plasma membrane, where it participates in the formation of the trans-SNARE complex by engaging t-SNARE SNAP25 (synaptosomal-associated protein 25) and v-SNARE synaptobrevin (a.k.a. vesicle-associated membrane protein2 or VAMP2) to allow fusion between the synaptic vesicle and plasma membrane. Two types of syntaxin 1 isoforms exist. Syntaxin-1A is a key protein in ion channel regulation and synaptic exocytosis.