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RevMab
anti-BOB-1 (human), Rabbit Monoclonal (RM378)
459
CHF
CHF 459.00
In stock
REV-31-1264-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using anti-BOB-1/OBF-1 rabbit monoclonal antibody (Clone RM378) at a 1:1250 dilution.
| Product Details | |
|---|---|
| Synonyms | POU Domain Class 2-associating Factor 1; OBF-1; OCA-B; OCT-binding Factor 1 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM378 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the C-terminus of human BOB-1/OBF-1. |
| Application |
Immunohistochemistry (IHC): 1:1000-1:2000 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human BOB-1/OBF-1 (B-cell-specific coactivator) (POU domain class 2-associating factor 1). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q16633 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
BOB-1 (OBF-1; POU domain class 2-associating factor 1) is a transcriptional co-activator that interacts with the transcription factors OCT-1 or OCT-2 in regulating transcription of immunoglobulin genes. BOB-1 is expressed principally by B-cell lymphocytes. In normal tonsil, the germinal center B cells all express BOB-1, while only scattered cells in the mantle zone express this protein. Expression of BOB-1, OCT-2 and PU.1 transcription factors are often down-regulated in classic Hodgkin lymphomas, in contrast to many cases of diffuse large B-cell lymphoma.