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RevMab
anti-CD23 (human), Rabbit Monoclonal (RM406)
459
CHF
CHF 459.00
In stock
REV-31-1292-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using Anti-CD23 Rabbit Monoclonal Antibody (Clone RM406) at a 1:200 dilution.
| Product Details | |
|---|---|
| Synonyms | Low Affinity Immunoglobulin epsilon Fc Receptor; BLAST-2; C-type Lectin Domain Family 4 Member J; Fc-epsilon-RII; Immunoglobulin E-binding Factor; Lymphocyte IgE Receptor |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM406 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to residues near the C-terminus of human CD23. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human to CD23. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P06734 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
CD23 (Fc epsilon RII; FcεRII) is a glycoprotein present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is a low-affinity receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, found on B cells. It is expressed on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma. Functionally, CD23 is involved in B cell growth and differentiation and IgE production. CD23 is known to have a role of transportation in antibody feedback regulation. CD23 has a soluble form that is a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.