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RevMab
anti-CD25 (human), Rabbit Monoclonal (RM418)
459
CHF
CHF 459.00
In stock
REV-31-1304-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human Hodgkin lymphoma tissue section using anti-CD25 rabbit monoclonal antibody (Clone RM418) at a 1:200 dilution.
| Product Details | |
|---|---|
| Synonyms | IL-2Ralpha |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM418 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the N-terminus of human CD25. |
| Application |
Immunohistochemistry (IHC): 1:100 -1:200 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human CD25 (IL2Rα). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P01589 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
CD25 (IL2 receptor alpha chain; IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors and oligodendrocytes. Though IL2RA has been used as a marker to identify CD4+FoxP3+ regulatory T cells in mice, it has been found that a large proportion of resting memory T cells constitutively express IL2RA in humans. IL2 plays an important role as a growth factor, differentiation factor and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity and inhibits granulocyte macrophage colony formation. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. IL2RA is expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, mastocytosis and tumor infiltrating lymphocytes. It functions as the receptor for HTLV-1 and is consequently expressed on neoplastic cells in adult T cell lymphoma/leukemia.