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RevMab
anti-Musashi 2 (human), Rabbit Monoclonal (RM422)
459
CHF
CHF 459.00
In stock
REV-31-1309-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human breast ductal carcinoma tissue section using anti-Musashi 2 rabbit monoclonal antibody (Clone RM422) at a 1:400 dilution.
| Product Details | |
|---|---|
| Synonyms | MSI2 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM422 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the internal region of human Musashi 2. |
| Application |
Immunohistochemistry (IHC): 1:100-1:400 dilution |
| Crossreactivity | Human |
| Specificity |
RM422 reacts to human Musashi 2. This antibody may also react to mouse or rat Musashi 2, as predicted by immunogen homology. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q96DH6 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Musashi 2, also known as MSI2 or MSI2H, is a 328 aa protein that localizes to the cytoplasm and contains two RRM (RNA recognition motif) domains. Expressed ubiquitously at low levels, MSI2 functions as an RNA binding protein that, by regulating the expression of target mRNAs, is thought to play a role in the proliferation and maintenance of stem cells within the central nervous system. MSI2 is subject to posttranslational phosphorylation and is upregulated in response to brain injury, suggesting a role in healing and brain tissue regeneration. Chromosomal aberrations involving the MSI2 gene are associated with the progression of chronic myeloid leukemia.