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RevMab
anti-TRK (pan) (human), Rabbit Monoclonal (RM423)
459
CHF
CHF 459.00
In stock
REV-31-1310-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue section using anti-Pan TRK rabbit monoclonal antibody (Clone RM423) at a 1:100 dilution.
| Product Details | |
|---|---|
| Synonyms | Tropomyosin Receptor Kinase; Tyrosine Receptor Kinase; High Affinity Nerve Growth Factor Receptor |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM423 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the C-terminus of human TRK. |
| Application |
Immunohistochemistry (IHC): 1:100-1:400 dilution |
| Crossreactivity | Human |
| Specificity |
RM423 reacts to human TRK. This antibody may also react to mouse or rat TRK, as predicted by immunogen homology. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P04629 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
The family of neurotrophic tyrosine kinase (NTRK1/2/3) gene encodes TrkA, TrkB and TrkC protein kinases. The three family members are activated by different neurotrophins: TrkA is activated by Nerve growth factor (NGF), TrkB by Brain-derived neurotrophic factor (BDNF) or neurotrophin-4 (NT-4) and TrkC by NT-3. Neurotrophin signaling activates cellular pathways involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, cell growth, differentiation and survival of sympathetic and nervous neurons. TRK, was initially identified in a colon carcinoma, is frequently activated in thyroid papillary carcinomas. Pan-Trk IHC is a time-efficient and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma.