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RevMab
anti-Annexin A1 (human), Rabbit Monoclonal (RM424)
459
CHF
CHF 459.00
In stock
REV-31-1311-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human colon tissue section using anti- Annexin A1 rabbit monoclonal antibody (Clone RM424) at a 1:100 dilution.
| Product Details | |
|---|---|
| Synonyms | Lipocortin-1; p35; Annexin-1; Calpactin-2; Calpactin II; Lipocortin I; Chromobindin-9; Phospholipase A2 Inhibitory Protein |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM424 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the N-terminus of human Annexin A1. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 dilution |
| Crossreactivity | Human |
| Specificity |
RM424 reacts to human Annexin A1. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P04083 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
The annexin superfamily consists of 13 calcium or calcium and phospholipid binding proteins with high biological and structural homology. Annexin-1 (ANXA1) is the first characterized member of the annexin family of proteins and is able to bind to cellular membranes in a calcium-dependent manner, promoting membrane fusion and endocytosis. Loss of function or expression of this gene has been detected in multiple tumors. Annexin A1 has anti-inflammatory properties and inhibits phospholipase A2 activity, can accumulate on internalized vesicles after EGF-stimulated endocytosis and may be required for a late stage in inward vesiculation. Annexin A1 has also been identified as one of the 'eat-me' signals on apoptotic cells that are to be recognized and ingested by phagocytes. Annexin A1, as an endogenous anti-inflammatory mediator, has roles in many diverse cellular functions, such as membrane aggregation, inflammation, phagocytosis, proliferation, apoptosis and tumorigenesis and cancer development.