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RevMab
anti-Nkx3.1 (human), Rabbit Monoclonal (RM430)
459
CHF
CHF 459.00
In stock
REV-31-1318-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human prostate cancer tissue section using anti-Nkx3.1 rabbit monoclonal antibody (Clone RM430) at a 1:200 dilution.
Figure 2: Immunohistochemical staining of formalin fixed and paraffin embedded human prostate section using anti-Nkx3.1 rabbit monoclonal antibody (Clone RM430) at a 1:200 dilution.
| Product Details | |
|---|---|
| Synonyms | Homeobox Protein Nkx-3.1; Homeobox Protein NK-3 Homolog A |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM430 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the N-terminus of human Nkx3.1. |
| Application |
Immunohistochemistry (IHC): 1:100-1:400 dilution |
| Crossreactivity | Human |
| Specificity |
RM430 reacts to human Nkx3.1. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q99801 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
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