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RevMab
anti-p70S6K (human), Rabbit Monoclonal (RM438)
459
CHF
CHF 459.00
In stock
REV-31-1329-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using anti-p70S6K antibody (RM438) at 1:400 dilution.
| Product Details | |
|---|---|
| Synonyms | Ribosomal Protein S6 Kinase |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM438 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the N-terminus of p70S6K. |
| Application |
Immunohistochemistry (IHC): 1:100-1:400 Western Blot: 1:1000-1:2000 |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human p70S6K. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P23443 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
The p70S6 kinase (p70 Ribosomal Protein S6 Kinase, p70S6K) is a 70kDa member of the ribosomal S6 kinase (RSK) family of serine/threonine kinases. p70S6 kinase is predominantly localized in the cytoplasm and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response and tissue repair. p70S6 kinase acts downstream of phosphoinositide (PI) 3-kinase and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70S6 kinase and overexpression are seen in some breast cancer cell lines.