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RevMab
anti-HDAC3 (human), Rabbit Monoclonal (RM439)
459
CHF
CHF 459.00
In stock
REV-31-1330-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human lung squamous carcinoma tissue sections using anti-HDAC3 antibody (RM439) at 1:200 dilution.
| Product Details | |
|---|---|
| Synonyms | Histone Deacetylase 3; RPD3-2; SMAP45 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM439 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the C-terminus of HDAC3. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 Western Blot: 1:1000-1:2000 |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human HDAC3. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | O15379 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
HDAC3 is a histone deacetylase and is responsible for the deacetylation of lysine residues on core histones and other histone substrates. The deacetylation of histones is important for transcriptional regulation, cell cycle progression and other developmental related functions. HDAC3 represses gene expression by participating in the transcriptional repressor activity of BCL6, by deacetylating H3K27 on enhancer elements. It is also thought to participate in transcriptional regulation through binding to YY1, a zinc-finger transcription factor. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. The HDAC3 gene is regarded as a potential tumor suppressor gene.