Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
RevMab
anti-ANO1 [TMEM16A] (human), Rabbit Monoclonal (RM440)
459
CHF
CHF 459.00
In stock
REV-31-1331-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human gastrointestinal stroma tissue sections using anti-ANO1 antibody (RM440) at 1:100 dilution.
| Product Details | |
|---|---|
| Synonyms | Anoctamin-1; DOG1 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM440 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the internal region of human ANO1. |
| Application |
Immunohistochemistry (IHC): 1:100-1:400 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human ANO1. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q5XXA6 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
ANO1 is a calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. It is required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. ANO1 acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Its overexpression was reported in esophageal squamous cell carcinoma and breast cancer progression.