Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
RevMab
5-Carboxylcytosine (5-caC) DNA Matched Antibody Pair
777
CHF
CHF 777.00
In stock
REV-31-1354-MK-KI011 SetCHF 777.00
Figure 1: Detection of 5-Carboxylcytosine (5-caC), in linear denatured DNA (426 bp). Sandwich ELISA using anti-Carboxylcytosine (5-caC) (clone RM462) as the capture antibody (50ng/well at 1ug/mL), and biotinylated anti-Adenine and Guanine (clone RM476) as the detection antibody (0.2ug/mL), followed by an AP conjugated streptavidin.
| Product Details | |
|---|---|
| Synonyms | 5-caC |
| Product Type | Set |
| Properties | |
| Application Set | Quantitative ELISA |
| Specificity |
This antibody pair detects 5-Carboxylcytosine (5-caC) in denatured DNA (single strand DNA). It does not react to non-methylated cytosine and other modified cytosine (5-mC, 5-hmC, or 5-fC) in DNA. This product includes capture and detection antibodies for Sandwich ELISA assays. |
| Crossreactivity | All |
| Quantity |
ELISA: |
| Assay Type | Sandwich |
| Detection Type | Colorimetric |
| Kit Contains |
1) Capture Antibody: Anti-5-Carboxylcytosine (5-caC) Rabbit Monoclonal Antibody, Clone RM462, 50 ug at 1.0 mg/mL in 50% Glycerol/PBS with 0.09% sodium azide, without BSA or other carrier proteins. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| Manual | No |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
5-Carboxylcytosine (5-caC) is a recently discovered modification of DNA. Just as 5-hydroxymethylcytosine (5-hmC) is generated when the Tet family of cytosine oxygenase enzymes converts 5-methylcytosine (5-mC), it has been shown that continued activity of the Tet proteins on hydroxymethylcytosine will generate 5-formylcytosine (5-fC) and 5-carboxylcytosine. It is believed that this conversion process may represent a pathway of DNA demethylation.
Related Products
