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RevMab
anti-Phospho-JNK1/2/3 (Thr183/Tyr185), Rabbit Monoclonal (RM464)
459
CHF
CHF 459.00
In stock
REV-31-1356-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin-fixed and paraffin-embedded human colon cancer tissue section using anti-Phospho-JNK1/2/3 (Thr183/Tyr185) rabbit monoclonal antibody (clone RM464) at a 1:100 dilution.
| Product Details | |
|---|---|
| Synonyms | c-Jun N-terminal Kinase; Mitogen-activated Protein Kinase; MAPK8; MAPK9; MAPK10 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM464 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A phospho-peptide corresponding to human Phospho-JNK1/2/3 (Thr183/Tyr185). |
| Application |
Western Blot (WB): 1:200-1:2000 |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human JNK1, JNK2 and JNK3 only when phosphorylated at Thr183 and Tyr185. There is no cross-reactivity to JNK that is not phosphorylated. This antibody may also react to mouse or rat Phospho-JNK1/2/3 (Thr183/Tyr185) as predicted by immunogen homology. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P45983, P45984, P53779 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
C-Jun N-terminal Kinase (JNK) is also known as Mitogen-activated protein kinase (MAPK8). It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.