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RevMab
anti-FAK (Focal adhesion kinase 1), Rabbit Monoclonal (RM472)
459
CHF
CHF 459.00
In stock
REV-31-1364-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human lung cancer tissue sections using Anti-FAK antibody (RM472) at 1:100 dilution.
| Product Details | |
|---|---|
| Synonyms | Focal Adhesion Kinase 1; Protein-tyrosine Kinase 2; PTK2 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM472 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to residues surrounding Tyr397 of human FAK1 (Focal adhesion kinase 1). |
| Application |
IHC: 1:100 - 1:200 WB: 1:100 - 1:400 |
| Crossreactivity | Human |
| Specificity |
RM472 reacts to human FAK (Focal adhesion kinase 1). This antibody may also react to mouse or rat FAK, as predicted by immunogen homology. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q05397 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
FAK1 (Focal Adhesion Kinase 1) is a non-receptor protein tyrosine kinase that is involved in the regulation of cell adhesion, migration, and survival. It is a member of the Src family of kinases. FAK1 is activated by binding to integrins, which are transmembrane proteins that mediate the attachment of cells to the extracellular matrix. When FAK1 is activated, it phosphorylates a number of downstream targets, including paxillin, tensin, and the small GTPase Ras. These phosphorylation events lead to the activation of a number of signaling pathways, including the MAPK pathway, the PI3K-AKT pathway, and the NF-κB pathway. The MAPK pathway is involved in the regulation of cell migration, survival, and proliferation. The PI3K-AKT pathway is involved in the regulation of cell survival and metabolism. The NF-κB pathway is involved in the regulation of inflammation and immunity.