anti-p42 MAPK (Erk2), Rabbit Monoclonal (RM483)

Specifications / Handling

More Information
Product Details
Synonyms	Mitogen-activated Protein Kinase Isoform p42; Extracellular Signal-regulated Kinase 2
Product Type	Recombinant Antibody
Properties
Clone	RM483
Isotype	Rabbit IgG
Source/Host	Rabbit
Immunogen/Antigen	A peptide corresponding to the C-terminus of human p42-MAPK (Erk2).
Application	Immunohistochemistry (IHC): 1:100-1:200 Western Blot (WB): 1:1000-1:2000
Crossreactivity	Human Mouse Rat
Specificity	This antibody reacts to human p42 MAPK (Erk2). This antibody may also react to mouse or rat Erk2 as predicted by immunogen homology.
Purity	Protein A purified.
Purity Detail	Protein A affinity purified from an animal origin-free culture supernatant.
Concentration	N/A
Formulation	Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Isotype Negative Control	Rabbit IgG
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Accession Number	P28482
Declaration	Manufactured by RevMab Biosciences.
Shipping and Handling
Shipping	BLUE ICE
Long Term Storage	-20°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Extracellular signal-regulated kinases 1 and 2 (also known as ERK1/2, p44/42, or MAPK3/1) belong to a family of conserved serine/threonine protein kinases known as mitogen-activated protein kinases (MAPKs) that are involved in many cellular programs such as proliferation, differentiation, motility and survival. The ERK1/2 signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors and cytokines. The primary activators of ERK1/2 are MEK1 and MEK2 which activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187 in ERK1 and ERK2, respectively. Several downstream targets of ERK1/2 have been identified, including p90RSK and the transcription factor Elk-1. ERK1/2 are negatively regulated by MAPK phosphatases as well as by chemical inhibitors of MEK. The ERK pathway is disrupted in many types of cancer and thus is an important target for diagnosis and treatment.

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