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RevMab
anti-CAIX (CA9), Rabbit Monoclonal (RM486)
459
CHF
CHF 459.00
In stock
REV-31-1378-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human stomach tissue sections using anti-CA9 rabbit monoclonal antibody (RM486) at 1:100 dilution.
Figure 2: Western Blot of SW620 cell lysate using anti-CA9 rabbit monoclonal antibody (RM486) at 1:2500 dilution.
| Product Details | |
|---|---|
| Synonyms | Carbonic Anhydrase IX; CA9, Renal Cell Carcinoma-associated Antigen G250; RCC-associated Antigen G250; P54/58N |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM486 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the C-terminus of human CAIX (CA9) (Carbonic Anhydrase 9). |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human CAIX (CA9) (Carbonic Anhydrase 9). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q16790 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CAIX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CAIX results in increased cell death under hypoxia. Therefore, CAIX has become a reliable histochemical marker of hypoxia.