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RevMab
anti-MUC-1 (Mucin-1) (human), Rabbit Monoclonal (RM489)
459
CHF
CHF 459.00
In stock
REV-31-1381-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer-lobular section using anti-Muc-1 rabbit monoclonal antibody (Clone RM489) at a 1:1000 dilution.
Figure 2: Western Blot of MCF-7 cell lysate using anti-Muc1 rabbit monoclonal antibody (RM489) at 1:1000 dilution.
| Product Details | |
|---|---|
| Synonyms | MUC1; Cancer Antigen 15-3 (CA 15-3); CD227; Breast Carcinoma-associated Antigen DF3; Episialin; H23AG |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM489 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the cytoplasmic domain of human Mucin-1. |
| Application |
Immunohistochemistry (IHC): 1:500-1:1000 |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human Muc-1 (Mucin-1). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P15941 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. MUC1 is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis, and sequential addition and processing of numerous O-linked glycans that are heavily sialylated. MUC1 is highly polymorphic and each allele encodes a product that contains a different number of repeats (between 30 and 90) leading to large differences in molecular weight of the protein. MUC1 is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells, and is expressed abundantly in >90% breast carcinomas and metastases. Overexpression, aberrant intracellular localization, and changes in glycosylation of the MUC1 protein have been associated with carcinomas.