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RevMab
anti-CDX2 (human), Rabbit Monoclonal (RM495)
459
CHF
CHF 459.00
In stock
REV-31-1387-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin-fixed and paraffin-embedded human colon cancer tissue sections using anti-CDX2 rabbit monoclonal antibody clone RM495 at a 1:100 dilution.
| Product Details | |
|---|---|
| Synonyms | Homeobox Protein CDX-2 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM495 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | Recombinant human CDX2. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human CDX2. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q99626 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
CDX2 is a caudal-type homeobox gene that encodes an intestine-specific transcription factor expressed early in intestinal development and that may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. CDX2 plays a role in early embryonic development of the intestinal tract and aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer. It is not expressed in the normal gastric mucosa. Loss of CDX2 protein expression has been correlated with loss of differentiation in colorectal cancers. CDX2 antibodies can be useful in distinguishing the gastrointestinal origin of metastatic adenocarcinomas and carcinoids.