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RevMab
anti-CD68 (human), Rabbit Monoclonal (RM496)
459
CHF
CHF 459.00
In stock
REV-31-1388-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin-fixed and paraffin-embedded human tonsil tissue sections using anti-CD68 rabbit monoclonal antibody (clone RM496) at a 1:500 dilution.
| Product Details | |
|---|---|
| Synonyms | Macrosialin; GP110; Scavenger Receptor Class D Member 1; SCARD1 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM496 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | Recombinant human CD68. |
| Application |
Immunohistochemistry (IHC): 1:100-1:500 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human CD68. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P34810 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
CD68 [Macrosialin; GP110; SCARD1] is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML) and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several acute myeloid leukemia studies.
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