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RevMab
anti-UP2 (Uroplakin-2) (human), Rabbit Monoclonal (RM507)
459
CHF
CHF 459.00
In stock
REV-31-1399-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin-fixed and paraffin-embedded human ureter tissue sections using anti-UP2 Rabbit Monoclonal Antibody (RM507) at 1:200 dilution.
| Product Details | |
|---|---|
| Synonyms | Uroplakin-2; UPII; Uroplakin II |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM507 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to residues near the C-terminus of human UP2. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human UP2. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | O00526 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
The protein components of uroplaques are composed of uroplakins (UPs), which are a family of transmembrane proteins, including UPIa (27 kDa), UPIb (28 kDa), UPII (15 kDa), and UPIIIa (47 kDa). UPs are exclusively expressed in the normal urothelium and are undetectable in non-urothelial tissues. They are usually present at the apical surface and cytoplasm of umbrella cells but absent in the intermediate and basal cells. Although UPs are the major differentiation products of the urothelium, they are not significantly downregulated during urothelial malignant transformation. Using immunohistochemical staining it was shown that more than half of invasive and metastatic urothelial carcinomas (UCs) continued to express UPs. Uroplakin II (UP II) is a 15 kDa protein component of urothelial plaques that enhance the permeability barrier of the urothelium. Uroplakin II (UPII) is considered as a sensitive marker for urothelial carcinoma (UC).