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RevMab
anti-CLDN 18.2, Rabbit Monoclonal (RM510)
468
CHF
CHF 468.00
In stock
REV-31-1402-00-R100100 µlCHF 468.00
Figure 1: Immunohistochemical staining of formalin-fixed and paraffin-embedded human stomach adenocarcinoma tissue sections using anti-CLDN18.2 Rabbit Monoclonal Antibody, Clone RM510, at 1:100 dilution.
| Product Details | |
|---|---|
| Synonyms | Claudin-18 Isoform A2 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM510 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to residues of human Claudin-18 Isoform A2. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 |
| Crossreactivity |
Human Mouse Rat |
| Specificity |
This antibody reacts to human CLDN18.2 (Claudin 18.2) (Isoform A2 of Claudin-18). This antibody may also react to mouse or rat CLDN18.2, as predicted by immunogen homology. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P56856 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lungs. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung-specific. CLDN18.2 is maintained during the course of malignant transformation and is thus frequently displayed on the surface of human gastric cancer cells.