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RevMab
anti-WT1 (human), Rabbit Monoclonal (RM516)
468
CHF
CHF 468.00
In stock
REV-31-1408-00-R100100 µlCHF 468.00
Figure 1: Immunohistochemical staining of formalin-fixed and paraffin-embedded human mesothelioma tissue sections using anti-WT1 Rabbit Monoclonal Antibody (Clone RM516) at 1:100 dilution for 1 hr at room temperature.
| Product Details | |
|---|---|
| Synonyms | Wilms Tumor Protein; WT33 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM516 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to residues near the N-terminus of human WT1. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human WT1 (Wilms tumor protein). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P19544 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilms tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilms tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma and desmoplastic small round cell tumor. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas.