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RevMab
anti-MUC-17 (Mucin-17) (human), Rabbit Monoclonal (RM517)
468
CHF
CHF 468.00
In stock
REV-31-1409-00-R100100 µlCHF 468.00
Figure 1: Immunohistochemical staining of formalin-fixed and paraffin-embedded human small intestine tissue sections using anti-Muc17 Rabbit Monoclonal Antibody (Clone RM517) at 1:100 dilution for 1 hr at room temperature.
| Product Details | |
|---|---|
| Synonyms | Mucin-17; Small Intestinal Mucin-3 (MUC-3) |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM517 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to residues near the C-terminus of human Muc17. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human Muc-17 (Mucin-17). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q685J3 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC-17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. MUC-17 interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. MUC-17 probably plays a role in maintaining homeostasis on mucosal surfaces. Increased expression of this molecule has been reported in colon cancer.
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