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RevMab
anti-SV2A, Rabbit Monoclonal (RM520)
468
CHF
CHF 468.00
In stock
REV-31-1412-00-R100100 µlCHF 468.00
Figure 1: Immunohistochemical staining of formalin-fixed and paraffin-embedded human pancreas tissue sections using anti-SV2A Rabbit Monoclonal Antibody (Clne RM520) at 1:100 dilution, for 1hr at room temperature.
| Product Details | |
|---|---|
| Synonyms | Synaptic Vesicle Glycoprotein 2A |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM520 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the N-terminus of human SV2A. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 |
| Crossreactivity |
Human Mouse Rat |
| Specificity |
This antibody reacts to human, mouse and rat SV2A (Synaptic vesicle glycoprotein 2A). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q7L0J3 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
SV2A (Synaptic Vesicle protein 2A) is an integral membrane glycoprotein present in synaptic vesicles. SV2s have 12 transmembrane domains predicted by sequence analysis. There are three characterized isoforms, SV2A, SV2B and SV2C. SV2A is expressed ubiquitously throughout the brain. SV2B has a more restricted distribution with varying degrees of coexpression with SV2A. SV2C is more closely related to SV2A but shows a very restricted expression pattern. The highest expression levels were observed in phylogenetically old brain areas like pallidum, the midbrain and the olfactory bulb. SV2A is probably involved in the maintenance of a pool of synaptic vesicles competent for calcium-stimulated exocytosis. SV2A is a highly glycosylated synaptic vesicle protein with homology to transmembrane transporters. This protein plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.