Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
RevMab
anti-LSD1+8a (human), Rabbit Monoclonal (RM523)
As low as
477
CHF
CHF 477.00
In stock
Only %1 left
REV-31-1415-00-R100100 µlCHF 477.00
NEW
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded LNCaP cells transfected with Empty Vector (EV) or LSD1+8a Expressing Vector, using Anti-LSD1+8a Rabbit Monoclonal Antibody (RM523) at 1:500 dilution.
| Product Details | |
|---|---|
| Synonyms | Lysine-Specific Demethylase 1 isoform 8a |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM523 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A synthetic peptide with an amino acid sequence corresponding to human LSD1 isoform 8a. |
| Application |
Western Blot (WB): 1:100-1:500 |
| Crossreactivity |
Human Mouse Rat |
| Specificity |
RM523 reacts to reacts to human LSD1+8a (isoform 8a). This antibody may also react to mouse or rat LSD1+8a, as predicted by immunogen homology. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| Accession Number | O60341 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
LSD1+8a (Lysine-Specific Demethylase 1 isoform 8a) is an alternatively spliced variant of the LSD1 (KDM1A) gene that includes the neuron-specific exon 8a. This isoform is predominantly expressed in the brain and plays a key role in neuronal differentiation and function. While canonical LSD1 regulates gene expression by demethylating histone H3 on lysine 4 (H3K4me1/2), the +8a variant shows altered substrate specificity and interacts with different cofactors, contributing to neuron-specific transcriptional programs. Dysregulation of LSD1+8a has been implicated in neurodevelopmental disorders and certain cancers.