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RevMab
anti-Integrin beta-6 (human), Rabbit Monoclonal (RM527)
As low as
477
CHF
CHF 477.00
In stock
Only %1 left
REV-31-1420-00-R100100 µlCHF 477.00
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Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human Triple-Negative Breast Cancer (TNBC) tissue, stained with anti-ITGB6 (Integrin beta-6) rabbit monoclonal antibody clone RM527 at 1:100 dilution.
| Product Details | |
|---|---|
| Synonyms | ITGB6 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM527 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the C-terminus of human Integrin β6. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 dilution Western Blot (WB): 1:1000-1:2000 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human Integrin β6. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| Accession Number | P18564 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Integrin β6 (ITGB6) is a transmembrane receptor subunit that pairs exclusively with integrin αv to form the αvβ6 integrin heterodimer. This receptor is normally expressed at low levels in healthy adult tissues but is upregulated during tissue injury, inflammation, and epithelial remodeling. Integrin β6 plays a key role in activating transforming growth factor-β (TGF-β) and mediating cell adhesion, migration, and signaling. Its overexpression has been associated with fibrosis and various epithelial cancers, where it contributes to tumor invasion and poor prognosis.