UbcH5c [UBE2D3] (human) (rec.) (untagged)

CHF 345.00
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SBB-CE0019-C100100 µgCHF 345.00
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Product Details
Synonyms Ubiquitin-conjugating Enzyme H5c; PUBC; UBC5C; Ubiquitin-protein Ligase D3; p53-regulated Ubiquitin-conjugating Enzyme
Product Type Protein
Source/Host E. coli
Sequence Human UBE2D3 (aa1-147) (Accession Nr. P61077) is untagged.
Crossreactivity Human
Application Typical working concentration range is 1-5µM.
MW ~17kDa
Purity ≥95% (SDS-PAGE)
Concentration Lot dependent.
Accession Number P61077
Formulation Liquid. In 50mM HEPES pH 8, 200mM sodium chloride, 10% glycerol (v/v), 1mM TCEP.
Other Product Data Click here for a Typical Lot-specific Product Datasheet from the Original Manufacturer
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by South Bay Bio.
Shipping and Handling
Shipping DRY ICE
Short Term Storage -80°C
Long Term Storage -80°C
Handling Advice Aliquot to avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -80°C.
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

UBE2D3 [UbcH5c] is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2D3 via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2D3-Ub thioester. UBE2D3 is capable of associating with numerous known E3 ligases including MDM2, which target proteins such as p53 for proteasomal degradation through polyubiquitination.

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