NEDP1 [SENP8] (human) (rec.) (His)

CHF 155.00
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SBB-DE0025-C05050 µgCHF 155.00
 
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Product Details
Synonyms NEDD8-specific Protease 1; Sentrin-specific Protease 8; Deneddylase-1; Sentrin/SUMO-specific Protease SENP8; DEN1; PRSC2
Product Type Protein
Properties
Source/Host E. coli
Sequence Human NEDP1 (aa2-212) (Accession Nr. Q96LD8) is fused at the N-terminus to a His-tag.
Crossreactivity Human
Application Typical working concentration range is 1-10nM.
MW ~27kDa
Purity ≥95% (SDS-PAGE)
Concentration Lot dependent.
Accession Number Q96LD8
Formulation Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP.
Other Product Data Click here for a Typical Lot-specific Product Datasheet from the Original Manufacturer
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by South Bay Bio.
Shipping and Handling
Shipping DRY ICE
Short Term Storage -80°C
Long Term Storage -80°C
Handling Advice Aliquot to avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -80°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
NEDP1 is a deconjugating enzyme with specificity towards NEDDylated substrates. NEDP1 discriminates between ubiquitinated and NEDDylated targets, despite similar C-terminal regions. NEDP1 is a protease which hydrolyzes the isopeptide bond between the C-terminus of NEDD8 and the respective lysine of the substrate protein to which the NEDD8 is covalently bound. NEDP1 is important in regulating cullin associated ubiquitin ligase enzymes such as those of the SCF (Skp-Cullin-Fbox) family and subsequently, it is important in regulating cell cycle progression and other biological functions.
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