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SynKinase
BI-D1870
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | BID1870 |
| Product Type | Chemical |
| Properties | |
| Formula | C19H23F2N5O2 |
| MW | 391.4 |
| CAS | 501437-28-1 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: S6K | Kinase Group: AGC | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | DTEKTGDVSARYDS-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
BI-D1870 is a small molecule, specific inhibitor of p90 RSK (ribosomal S6 kinase) isoforms RSK1, RSK2, RSK3 and RSK4, both in vitro and in vivo, with IC(50)s are 31nM, 24nM, 18nM, 15nM, respectively. It shows a 10- to 100-fold selectivity for RSK over MST2, GSK-3β, MARK3, CK1 and Aurora B.
Product References
- BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo: G.P. Sapkota, et al.; Biochem. J. 401, 29 (2007)
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