BIX 02565

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SYN-1228-M0011 mgCHF 128.00
SYN-1228-M0055 mgCHF 270.00
SYN-1228-M01010 mgCHF 397.00
SYN-1228-M05050 mgCHF 1'263.00
SYN-1228-M100100 mgINQ
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Product Details
Synonyms BIX-02565
Product Type Chemical
Formula C26H30N6O2
MW 458.6
CAS 1311367-27-7
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: RSK2 | Kinase Group: AGC | Substrate: Serine-Threonine
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF
BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1nM. BIX 02565 also has inhibitory effects on LRRK2, RET, CLK2, FLT3 and PDGFR. BIX 02565 can be used in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure.
Product References
  1. Indole RSK inhibitors. Part 2: optimization of cell potency and kinase selectivity: T.M. Kirrane, et al.; Bioorg. Med. Chem. Lett. 22, 738 (2012)
  2. Mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal S6 kinase 2 inhibitors: R.M. Fryer, et al.; J. Pharmacol. Exp. Ther. 340, 492 (2012)
  3. A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870: A.J. Edgar, et al.; Biosci. Rep. 34, e00091 (2014)
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