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SynKinase
BIX 02565
CHF 0.00
In stock
SYN-1228-M0011 mgCHF 128.00
SYN-1228-M0055 mgCHF 270.00
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SYN-1228-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | BIX-02565 |
| Product Type | Chemical |
| Properties | |
| Formula | C26H30N6O2 |
| MW | 458.6 |
| CAS | 1311367-27-7 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data | Target: RSK2 | Kinase Group: AGC | Substrate: Serine-Threonine |
| InChi Key | ZHMXXVNQAFCXKK-QGZVFWFLSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1nM. BIX 02565 also has inhibitory effects on LRRK2, RET, CLK2, FLT3 and PDGFR. BIX 02565 can be used in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure.
Product References
- Indole RSK inhibitors. Part 2: optimization of cell potency and kinase selectivity: T.M. Kirrane, et al.; Bioorg. Med. Chem. Lett. 22, 738 (2012)
- Mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal S6 kinase 2 inhibitors: R.M. Fryer, et al.; J. Pharmacol. Exp. Ther. 340, 492 (2012)
- A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870: A.J. Edgar, et al.; Biosci. Rep. 34, e00091 (2014)
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