CC-401 hydrochloride

CHF 138.00
In stock
SYN-1028-M0011 mgCHF 138.00
SYN-1028-M0055 mgCHF 239.00
SYN-1028-M01010 mgCHF 371.00
SYN-1028-M05050 mgCHF 1'251.00
SYN-1028-M100100 mgCHF 2'173.00
 
More Information
Product Details
Synonyms CC401
Product Type Chemical
Properties
Formula C22H24N6O . HCl
MW 388.4 . 36.5
CAS 1438391-30-0
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: JNK | Kinase Group: CMGC | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key OIBVXKYKWOUGAO-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
CC-401 is a competitive inhibitor of the ATP binding site in the active, phosphorylated, form of JNK. This prevents JNK from phosphorylating its various target molecules, including the amino terminus of c-Jun. It is a potent inhibitor of all three forms of JNK (Ki of 25-50 nM), and has at least 40-fold selectivity for JNK compared with other related kinases, including: p38, ERK, IKK2, PKC, Lck, and ZAP70. CC-401 acts to inhibit JNK signaling by competitive binding to the adenosine triphosphate-binding site in the active, phosphorylated, form of JNK, resulting in inhibition of the phosphorylation of JNK targets, such as the amino-terminal activation domain of the transcription factor, c-Jun. In cell-based assays, 1-5 muM CC-401 provides specific JNK inhibition.
Product References
  1. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis: F.Y. Ma, et al.; J. Am. Soc. Nephrol. 18, 472 (2007)
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