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SynKinase
Canertinib
71
CHF
CHF 71.00
In stock
SYN-1030-M0011 mgCHF 71.00
SYN-1030-M0055 mgCHF 92.00
SYN-1030-M01010 mgCHF 99.00
SYN-1030-M05050 mgCHF 369.00
SYN-1030-M100100 mgCHF 610.00
| Product Details | |
|---|---|
| Synonyms | CI1033; PD-183805 |
| Product Type | Chemical |
| Properties | |
| Formula | C24H25ClFN5O3 |
| MW | 486.0 |
| CAS | 267243-28-7 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: EGFR | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | OMZCMEYTWSXEPZ-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Canertinib is an orally bio-available EGFR inhibitor with potential anti-neoplastic and radio-sensitizing activities. It has IC(50) values of 1.5nM and 9.0nM against EGFR and ErbB2 respectively, with no activity against PDGFR, FGFR, InsR, PKC, or CDK1/2/4.
Product References
- The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux: C. Erlichman, et al.; Cancer Res. 61, 739 (2001)
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