SynKinase

CP-724714

Name: CP-724714
Brand: SynKinase
SKU: SYN-1033
Price: 114.00 CHF
Availability: InStock

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SYN-1033-M0011 mgCHF 114.00

SYN-1033-M0055 mgCHF 184.00

SYN-1033-M01010 mgCHF 312.00

SYN-1033-M05050 mgCHF 1’015.00

SYN-1033-M100100 mgINQ

Specifications / Handling

More Information
Product Details
Synonyms	CP724714
Product Type	Chemical
Properties
Formula	C₂₇H₂₇N₅O₃
MW	469.5
CAS	383432-38-0
Purity Chemicals	≥95%
Appearance	Solid.
Solubility	Soluble in DMSO or ethanol.
Declaration	Manufactured by SynKinase.
Other Product Data	Target: HER2 \| Kinase Group: RTK \| Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	LLVZBTWPGQVVLW-SNAWJCMRSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

CP-724714 is an oral, selective and potent ErbB-2 (HER2) kinase inhibitor with an IC(50) of 10 nM. It has >640-fold selectivity for ErbB-2 (HER2) over EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met.

Product-specific References

Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor: J.P. Jani, et al.; Cancer Res. 67, 9887 (2007)

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