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Product Details
Synonyms JNJ38877605
Product Type Chemical
Formula C19H13F2N7
MW 377.4
CAS 943540-75-8
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: c-MET | Kinase Group: RTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
JNJ38877605 is an orally bio-available, small-molecule, c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (c-MET enzyme and Phospho-MET IC(50) values of 4nM and 50nM, respectively) and highly specific (selective over 229 other kinases tested).
Product References
  1. MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors: V. Cepero, et al.; Cancer Res. 70, 7580 (2010)
  2. Targeting c-Met in melanoma: Mechanism of resistance and efficacy of novel combinatorial inhibitor therapy: D. Etnyre, et al.; Cancer Biol. Ther. 15, 1129 (2014)
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