SynKinase

AMG-458

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Product Details
Synonyms	AMG458
Product Type	Chemical
Properties
Formula	C₃₀H₂₉N₅O₅
MW	539.6
CAS	913376-83-7
Purity Chemicals	≥95%
Appearance	Solid.
Solubility	Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration	Manufactured by SynKinase.
Other Product Data	Target: mTOR \| Kinase Group: Atypical (PIKK) \| Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	GLBZSOQDAOLMGC-UHFFFAOYSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

AMG-458 is a potent inhibitor of c-Met with an IC(50) of 60nM and displays selectivity against VEGFR2.

Product References

Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458): L. Liu, et al.; J. Med. Chem. 51, 3688 (2008)

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