AMG-458

CHF 150.00
In stock
SYN-1144-M0011 mgCHF 150.00
SYN-1144-M0055 mgCHF 311.00
SYN-1144-M01010 mgCHF 425.00
SYN-1144-M05050 mgCHF 1'257.00
SYN-1144-M100100 mgCHF 1'909.00
 
More Information
Product Details
Synonyms AMG458
Product Type Chemical
Properties
Formula C30H29N5O5
MW 539.6
CAS 913376-83-7
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: mTOR | Kinase Group: Atypical (PIKK) | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key GLBZSOQDAOLMGC-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
AMG-458 is a potent inhibitor of c-Met with an IC(50) of 60nM and displays selectivity against VEGFR2.
Product References
  1. Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458): L. Liu, et al.; J. Med. Chem. 51, 3688 (2008)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.