MK-2461

CHF 198.00
In stock
SYN-1149-M0011 mgCHF 198.00
SYN-1149-M0055 mgCHF 311.00
SYN-1149-M01010 mgCHF 503.00
SYN-1149-M05050 mgCHF 1'891.00
SYN-1149-M100100 mgCHF 2'741.00
More Information
Product Details
Synonyms MK2461
Product Type Chemical
Properties
Formula C24H25N5O5S
MW 495.6
CAS 917879-39-1
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: FGFR | Kinase Group: RTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key JGEBLDKNWBUGRZ-HXUWFJFHSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met kinases (N1100Y, Y1230C, Y1230H, Y1235D, and M1250T) with IC(50) values of 0.4 to 2.5nM.

Product References
  1. MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor: B.S. Pan, et al.; Cancer Res. 70, 1524 (2010)
  2. Tetraspanin-enriched microdomains regulate digitation junctions: C. Huang, et al.; Cell. Mol. Life Sci. doi.org/10.1007/s00018-018-2803-2 (2018)
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