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SynKinase
MK-2461
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | MK2461 |
| Product Type | Chemical |
| Properties | |
| Formula | C24H25N5O5S |
| MW | 495.6 |
| CAS | 917879-39-1 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: FGFR | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | JGEBLDKNWBUGRZ-HXUWFJFHSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met kinases (N1100Y, Y1230C, Y1230H, Y1235D, and M1250T) with IC(50) values of 0.4 to 2.5nM.
Product References
- MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor: B.S. Pan, et al.; Cancer Res. 70, 1524 (2010)
- Tetraspanin-enriched microdomains regulate digitation junctions: C. Huang, et al.; Cell. Mol. Life Sci. doi.org/10.1007/s00018-018-2803-2 (2018)
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