Gefitinib

CHF 48.00
In stock
SYN-1042-M0011 mgCHF 48.00
SYN-1042-M0055 mgCHF 66.00
SYN-1042-M01010 mgCHF 78.00
SYN-1042-M05050 mgCHF 144.00
SYN-1042-M100100 mgCHF 239.00
 
More Information
Product Details
Synonyms ZD1839; Iressa
Product Type Chemical
Properties
Formula C22H24ClFN4O3
MW 446.9
CAS 184475-35-2
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: EGFR - HER2 | Kinase Group: RTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key XGALLCVXEZPNRQ-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Gefitinib is a selective, orally available epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. In NR6wtEGFR and NR6W cells, it inhibits Tyr1173, Tyr992, Tyr1173 and Tyr992 with IC(50) values of 37nM, 37nM, 26nM and 57nM, respectively.
Product References
  1. ZD1839 ('Iressa') as an anticancer agent: J. Baselga & S.D. Averbuch; Drugs 60, 33 (2000)
  2. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor: F. Ciardiello, et al.; Clin. Cancer Res. 6, 2053 (2000)
  3. Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor: D. McKillop, et al.; Mol. Cancer Ther. 4, 641 (2005)
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