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GW-441756
INQ
In stock
SYN-1044-M0011 mgCHF 85.00
SYN-1044-M0055 mgCHF 142.00
SYN-1044-M01010 mgCHF 163.00
SYN-1044-M05050 mgCHF 646.00
SYN-1044-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | GW441756 |
| Product Type | Chemical |
| Properties | |
| Formula | C17H13N3O |
| MW | 275.3 |
| CAS | 504433-23-2 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: TrkA | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | NXNQLECPAXXYTR-LCYFTJDESA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
GW441756 is an orally active, potent and highly selective TrkA tyrosine kinase inhibitor (IC(50) of 2nM). It specifically blocks TrkA-induced cell death in a dose-dependent manner.
Product References
- Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway: T.A. Kudo, et al.; Genes Cells 16, 1121 (2011)
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