SynKinase

GW-441756

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SYN-1044-M0011 mgCHF 85.00
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SYN-1044-M05050 mgCHF 646.00
SYN-1044-M100100 mgINQ
 
More Information
Product Details
Synonyms GW441756
Product Type Chemical
Properties
Formula C17H13N3O
MW 275.3
CAS 504433-23-2
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: TrkA | Kinase Group: RTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key NXNQLECPAXXYTR-LCYFTJDESA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
GW441756 is an orally active, potent and highly selective TrkA tyrosine kinase inhibitor (IC(50) of 2nM). It specifically blocks TrkA-induced cell death in a dose-dependent manner.
Product References
  1. Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway: T.A. Kudo, et al.; Genes Cells 16, 1121 (2011)
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