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Ki20227
120
CHF
CHF 120.00
In stock
SYN-1049-M0011 mgCHF 120.00
SYN-1049-M0055 mgCHF 198.00
SYN-1049-M01010 mgCHF 287.00
SYN-1049-M05050 mgCHF 988.00
SYN-1049-M100100 mgCHF 1'700.00

Product Details | |
---|---|
Synonyms | Ki-20227 |
Product Type | Chemical |
Properties | |
Formula | C24H24N4O5S |
MW | 480.5 |
CAS | 623142-96-1 |
Purity Chemicals | ≥95% |
Appearance | Solid. |
Solubility | Soluble in DMSO or ethanol. |
Declaration | Manufactured by SynKinase. |
Other Product Data |
Target: c-fms | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
InChi Key | SHPFDGWALWEPGS-UHFFFAOYSA-N |
Shipping and Handling | |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents | |
MSDS |
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Product Specification Sheet | |
Datasheet |
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Ki20227 is a c-fms tyrosine kinase inhibitor. It has IC(50) values of 2, 12, 451 and 217nM for c-Fms, VEGFR-2, c-Kit and PDGFRβ respectively.
Product References
- A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model: H. Ohno, et al.; Mol. Cancer Ther. 5, 2634 (2006)
- The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model: H. Ohno, et al.; Eur. J. Immunol. 38, 283 (2008)
- M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis: Y. Kubota, et al.; J. Exp. Med. 206, 1089 (2009)