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SynKinase
PF-04217903
CHF 0.00
In stock
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Product Details | |
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Synonyms | PF04217903 |
Product Type | Chemical |
Properties | |
Formula | C19H16N8O |
MW | 372.4 |
CAS | 956905-27-4 |
Purity Chemicals | ≥95% |
Appearance | Solid. |
Solubility | Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. |
Declaration | Manufactured by SynKinase. |
Other Product Data |
Target: MET | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
InChi Key | PDMUGYOXRHVNMO-UHFFFAOYSA-N |
Shipping and Handling | |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents | |
MSDS | Download PDF |
Product Specification Sheet | |
Datasheet | Download PDF |
Description
PF04217903 is a novel orally bio-available, small molecule tyrosine kinase inhibitor with potential anti-neoplastic activity. It is an extremely selective MET inhibitor, with an IC(50) of 4.8nM.
Product References
- Sensitivity of selected human tumor models to PF-04217903, a novel selective c-Met kinase inhibitor: H.Y. Zou, et al.; Mol. Cancer Ther. 11, 1036 (2012)