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SynKinase
PD-173955
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | PD173955 |
| Product Type | Chemical |
| Properties | |
| Formula | C21H16Cl2N4OS |
| MW | 443.4 |
| CAS | 260415-63-2 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Abl - BCR | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | VAARYSWULJUGST-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
PD173955 is an ATP-competitive, dual Src/Bcr-Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC(50) of 1-2nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 also inhibits Src kinase activity in vitro with an IC(50) of 22nM and could represent a novel class of anti-mitotic drug.
Product References
- Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571): B. Nagar, et al.; Cancer Res. 62, 4236 (2002)
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