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SynKinase
PD-173955-Analog1
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | PD173955-Analog1 |
| Product Type | Chemical |
| Properties | |
| Formula | C21H14Cl2N4O3 |
| MW | 441.3 |
| CAS | 185039-99-0 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. Slightly soluble (<1mg/ml) in water. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Abl - BCR | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | RBURTLAMOSHNGX-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
PD173955-Analog1 is a potent c-Src inhibitor with an IC(50) value of 9nM. It is also a weaker inhibitor of PDGFR, FGFR and EGFR with IC(50) values of 130nM, 110nM and 190nM respectively.
Product References
- Src activation regulates anoikis in human colon tumor cell lines: T.C Windham, et al.; Oncogene 21, 7797 (2002)
- New effective inhibitors of the Abelson kinase: G.A. Kraus, et al.; Bioorg. Med. Chem. 18, 6316 (2010)
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