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Product Details
Synonyms PD173955-Analog1
Product Type Chemical
Formula C21H14Cl2N4O3
MW 441.3
CAS 185039-99-0
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol. Slightly soluble (<1mg/ml) in water.
Declaration Manufactured by SynKinase.
Other Product Data Target: Abl - BCR | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
PD173955-Analog1 is a potent c-Src inhibitor with an IC(50) value of 9nM. It is also a weaker inhibitor of PDGFR, FGFR and EGFR with IC(50) values of 130nM, 110nM and 190nM respectively.
Product References
  1. Src activation regulates anoikis in human colon tumor cell lines: T.C Windham, et al.; Oncogene 21, 7797 (2002)
  2. New effective inhibitors of the Abelson kinase: G.A. Kraus, et al.; Bioorg. Med. Chem. 18, 6316 (2010)
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