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AdipoGen Life Sciences
Altenusin
170
CHF
CHF 170.00
In stock
AG-CN2-0143-M0011 mgCHF 170.00
AG-CN2-0143-M0055 mgCHF 620.00
| Product Details | |
|---|---|
| Synonyms | MS 341 |
| Product Type | Chemical |
| Properties | |
| Formula |
C15H14O6 |
| MW | 290.3 |
| CAS | 31186-12-6 |
| Source/Host Chemicals | Isolated from Penicillium sp. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in methanol, ethanol or DMSO. |
| InChi Key | ADPBTBPPIIKLEH-UHFFFAOYSA-N |
| Smiles | COC1=CC(O)=C(C(O)=O)C(=C1)C1=CC(O)=C(O)C=C1C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic [7].
- Antifungal penicillide [8].
- Non-competitive, specific neutral sphingomyelinase (N-SMase) inhibitor [2].
- Strong pp60c-Src inhibitor [3].
- Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases [3].
- Myosin light chain kinase inhibitor [1].
- Exhibits anti-HIV-1 integrase activity [4].
- Cytotoxic activity against mouse lymphoma cells [6].
- Anti-protozoan, trypanothione reductase (TR) inhibitor [5].
- Phytotoxin [9].
Product References
- Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur: S. Nakanishi, et al.; Biosci. Biotechnol. Biochem. 59, 1333 (1995)
- Alutenusin, a specific neutral sphingomyelinase inhibitor, produced by Penicillium sp. FO-7436: R. Uchida, et al.; J. Antibiot. 52, 572 (1999)
- Fungal Metabolites as Potent Protein Kinase Inhibitors: Identification of a Novel Metabolite and Novel Activities of Known Metabolites: M. Oyama, et al.; Lett. Drug Des. Disc. 1, 24 (2004)
- HIV-1 Integrase Inhibitors: 2003-2004 Update: R. Dayan, et al.; Med. Res. Rev. 26, 271 (2006)
- Altenusin, a biphenyl isolated from the endophytic fungus Alternaria sp., inhibits trypanothione reductase from Trypanosoma cruzi: B.B. Cota, et al.; FEMS Microbiol. Lett. 285, 177 (2008)
- Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense: A.H. Aly, et al.; J. Nat. Prod. 71, 972 (2008)
- Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp.: Q.X. Wang, et al.; Fitoterapia 83, 209 (2012)
- Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis: S. Johann, et al.; Rev. Iberoam. Micol. 29, 205 (2012)
- Identification of Alternaria alternata mycotoxins by LC-SPE-NMR and their cytotoxic effects to soybean (Glycine max) cell suspension culture: G.D. de Souza, et al.; Molecules 18, 2528 (2013)
- Development of Acid Hydrolysis-Based UPLC–MS/MS Method for Determination of Alternaria Toxins and Its Application in the Occurrence Assessment in Solanaceous Vegetables and Their Products: H. Tang, et al.; Toxins 15, 201 (2023)
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