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AdipoGen Life Sciences
Aurodox
180
CHF
CHF 180.00
In stock
AG-CN2-0133-M0011 mgCHF 180.00
AG-CN2-0133-MM252.5 mgCHF 390.00
| Product Details | |
|---|---|
| Synonyms | 1-Methylmocimycin; Antibiotic X 5108; Goldinodox; Goldinomycin; NSC 233989 |
| Product Type | Chemical |
| Properties | |
| Formula |
C44H62N2O12 |
| MW | 811.0 |
| CAS | 12704-90-4 |
| Source/Host Chemicals | Isolated from Streptomyces sp. K06-0806. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in methanol or chloroform. Insoluble in water. |
| InChi Key | NTAHMPNXQOYXSX-WKSONYIQSA-N |
| Smiles | [H][C@@]1(O[C@@]([H])([C@H](C)[C@H](OC)C(\C)=C\C=C\CNC(=O)[C@@H](CC)[C@@]2(O)O[C@@]([H])(\C=C\C=C/C)C(C)(C)[C@@H](O)[C@H]2O)[C@@H](O)[C@H]1O)\C=C\C=C\C=C(/C)C(=O)C1=C(O)C=CN(C)C1=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic [2,3]
- Protein biosynthesis inhibitor by binding to elongation factor Tu (EF-Tu) [4-7].
- Type 3 secretion system (T3SS) inhibitor [8].
- Growth promotor in poultry [1].
Product References
- A New Antibiotic, X-5108, for Improved Growth and Feed Conversion in Poultry: W.L. Marusich, et al.; Poult. Sci. 53, 936 (1974)
- Feedback inhibition of the synthesis of an antibiotic: aurodox (X-5108): C. Liu, et al.; J. Antibiot. 30, 244 (1977)
- Increased production of the antibiotic aurodox (X-5108) by aurodox-resistant mutants: J. Unowsky & D.C. Hoppe; J. Antibiot. 31, 662 (1978)
- Stimulation of Escherichia coli elongation factor Tu-dependent GTP hydrolysis by aminoacyl oligonucleotides in the presence of aurodox: P. Bhuta & S. Chladek; FEBS Lett. 122, 113 (1980)
- Synthetic analogs of aurodox and kirromycin active on elongation factor Tu from Escherichia coli: G. Chinali; J. Antibiot. 34, 1039 (1981)
- Effects of nucleotide- and aurodox-induced changes in elongation factor Tu conformation upon its interactions with aminoacyl transfer RNA. A fluorescence study: V.A. Dell, et al.; Biochemistry 29, 1757 (1990)
- Conformational change of elongation factor Tu (EF-Tu) induced by antibiotic binding. Crystal structure of the complex between EF-Tu.GDP and aurodox: L. Vogeley, et al.; J. Biol. Chem. 276, 17149 (2001)
- A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium: K. Kimura, et al.; J. Antibiot. 64, 197 (2011)
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