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AdipoGen Life Sciences
Streptochlorin
100
CHF
CHF 100.00
In stock
AG-CN2-0141-C250250 µgCHF 100.00
AG-CN2-0141-M0011 mgCHF 300.00
| Product Details | |
|---|---|
| Synonyms | SF 2583A; 12815A; 4-Chloro-5-(3-indolyl)oxazole; 3-(4-Chloro-5-oxazolyl)-1H-indole |
| Product Type | Chemical |
| Properties | |
| Formula |
C11H7ClN2O |
| MW | 218.6 |
| CAS | 120191-51-7 |
| Source/Host Chemicals | Isolated from Streptomyces roseolilacinus. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Crystalline solid. |
| Solubility | Soluble in DMSO or methanol. Insoluble in water or hexane. |
| InChi Key | BKYJGKRXUHPPLR-UHFFFAOYSA-N |
| Smiles | ClC1=C(OC=N1)C1=CNC2=CC=CC=C12 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic [1].
- TNF-α-induced NF-κB activation inhibitor [1].
- Antiangiogenic [1].
- Apoptosis inducer [2-4].
- Anticancer compound. Selective cytotoxic against several cancer cell lines [2-4].
- Tyrosinase inhibitor [5].
Product References
- Streptochlorin, a marine natural product, inhibits NF-kappaB activation and suppresses angiogenesis in vitro: I. K. Choi, et al.; J. Microbiol. Biotechnol. 17, 1338 (2007)
- Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp. 04DH110: H. J. Shin, et al.; J. Microbiol. Biotechnol. 17, 1403 (2007)
- Streptochlorin isolated from Streptomyces sp. induces apoptosis in human hepatocarcinoma cells through a reactive oxygen species-mediated mitochondrial pathway: D. Y. Shin, et al.; J. Microbiol. Biotechnol. 18, 1862 (2008)
- Induction of apoptosis by streptochlorin isolated from Streptomyces sp. in human leukemic U937 cells: C. Park, et al.; Toxicol. In Vitro 22, 1573 (2008)
- Physicochemical characters of a tyrosinase inhibitor produced by Streptomyces roseolilacinus NBRC 12815: T. Nakashima, et al.; Biol. Pharm. Bull. 32, 832 (2009)
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