PF-562271

CHF 96.00
In stock
SYN-1064-M0011 mgCHF 96.00
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More Information
Product Details
Synonyms PF562271
Product Type Chemical
Properties
Formula C21H20F3N7O3S
MW 507.5
CAS 717907-75-0
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: FGFR | Kinase Group: RTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key MZDKLVOWGIOKTN-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was evaluated against multiple kinases and displays >100x selectivity against a long list of nontarget kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/mL using injections.
Product References
  1. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271: W.G. Roberts, et al.; Cancer Res. 68, 1935 (2008)
  2. Selectivity data: assessment, predictions, concordance, and implications. C. Gao, et al.; J. Med. Chem. 56, 6991 (2013)
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