Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
SynKinase
PF-4618433
CHF 0.00
In stock
SYN-1163-M0011 mgCHF 270.00
SYN-1163-M0055 mgCHF 546.00
SYN-1163-M01010 mgCHF 858.00
SYN-1163-M05050 mgINQ
SYN-1163-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | PF4618433 |
| Product Type | Chemical |
| Properties | |
| Formula | C24H27N7O2 |
| MW | 445.5 |
| CAS | 1166393-85-6 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PYK2 - FAK | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | NJARPUHZDSAXPL-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Potent and selective PYK2 inhibitor. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent increases in both alkaline phosphatase activity and mineralization.
Product References
- Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design: S. Han, et al.; J. Biol. Chem. 284, 13193 (2009)
- Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors: S.K. Bhattacharya, et al.; Bioorg. Med. Chem. Lett. 22, 7523 (2012)
- Non-canonical pathway induced by Wnt3a regulates b-catenin via Pyk2 in differentiating human neural progenitor cells: V.A.N. Talabattula, et al.; BBRC 491, 40 (2017)
Related Products
