PF-4618433

CHF 227.00
In stock
SYN-1163-M0011 mgCHF 227.00
SYN-1163-M0055 mgCHF 461.00
SYN-1163-M01010 mgCHF 724.00
SYN-1163-M05050 mgCHF 2'568.00
SYN-1163-M100100 mgCHF 4'148.00
 
More Information
Product Details
Synonyms PF4618433
Product Type Chemical
Properties
Formula C24H27N7O2
MW 445.5
CAS 1166393-85-6
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: PYK2 - FAK | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key NJARPUHZDSAXPL-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Potent and selective PYK2 inhibitor. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent increases in both alkaline phosphatase activity and mineralization.
Product References
  1. Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design: S. Han, et al.; J. Biol. Chem. 284, 13193 (2009)
  2. Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors: S.K. Bhattacharya, et al.; Bioorg. Med. Chem. Lett. 22, 7523 (2012)
  3. Non-canonical pathway induced by Wnt3a regulates b-catenin via Pyk2 in differentiating human neural progenitor cells: V.A.N. Talabattula, et al.; BBRC 491, 40 (2017)
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